This stimulating new edition of the well-respected title primarily covers medically important antimicrobial agents, but also includes some compounds not in current medical use, which have been invaluable as research tools in biochemistry. The book's coverage reflects the evolution of molecular biology's impact on our understanding of the mechanisms of antimicrobial action and drug resistance. New material deals with the remarkable recent developments in unraveling the complex molecular details of drug interactions with key targets. The new addition also reviews key advances in the biochemistry and molecular biology of drug-resistant pathogens.