The fourth edition of this leading book provides an authoritative, comprehensive and complete account of the neuronal disorders of the lower gastrointestinal tract in children. The book has been fully updated to reflect major advances have occurred both in the understanding as well as the treatment of Hirschprung's disease. Contents have been revised to include discussion of the latest therapies such as stem cell therapies, the epidemiology and association with multiple endocrine neoplasia and also discuss approaches to diagnosis such as radioloy and manometry. A chapter on Hischrpung's disease in adolescents and adults brings a new perspective to the topic. The follow up care and long-term outcomes of patients who have undergone therapy as well as intestinal transplantation options are also addressed in his edition.With 14 new chapters added and the contents updated and re worked this edition is authored by the leading current experts in their respective fields