The Tennessee 45th Infantry Regiment was organized at Camp Trousdale, Tennessee, in December, 1861. It participated in the Battle of Shiloh, was active at Baton Rouge, then served in the Jackson area. Later it was assigned to J.C. Brown's, Brown's and Reynolds' Consolidated, and Palmer's Brigade, Army of Tennessee. In November, 1863, it was consolidated with the 23rd Infantry Battalion. The regiment took an active part in the campaigns of the army from Murfreesboro to Atlanta, moving with General Hood back into Tennessee, but it was not engaged at Franklin and Nashville. It ended the war in North Carolina. The unit sustained 112 casualties at Murfreesboro, lost forty-three percent of the 226 at Chickamauga, and reported 12 men disabled at Missionary Ridge. The 45th/23rd Battalion totaled 316 men and 340 arms in December, 1863. Few surrendered in April, 1865.