this book constitutes the thoroughly refereed post-conference proceedings of the second international conference on mobile computing, applications, and services (mobicase 2010) held in santa clara, ca, usa, during october 25-28, 2010. the 15 revised full papers presented were carefully selected from numerous submissions. conference papers are organized in six technical sessions, covering the topics of mobile web and mash-ups, software engineering and development tools, cross-layer approaches, location-based services, mobile healthcare, and mobile social networking. furthermore the volume includes two workshops on mobile computing and mobile security as well as four poster papers.