Each story in the collection is centered on a person who is making his living by some novel and extraordinary means (a "queer trade", using the word "queer" in the sense of "peculiar"). To gain admittance one must have invented a unique means of earning a living and the subsequent trade being the main source of income. The framing narrative by "Cherub" Swinburne describes his quest for The Club of Queer Trades with his friend Basil Grant, a retired judge, and Rupert Grant, a private detective who is Basil's younger brother. Each of the stories describes their encounter with one of the trades.