This issue of Thoracic Surgery Clinics, guest edited by Drs. Dean Donahue and Hugh G. Auchincloss, is devoted to Thoracic Outlet Syndrome. Drs. Donahue and Auchincloss have assembled expert authors to review the following topics: Embryology and Anatomy of the Thoracic Outlet; Evaluation of Patients with Neurogenic Thoracic Outlet Syndrome; Reoperation for Persistent or Recurrent Neurogenic Thoracic Outlet Syndrome; Surgical Technique: Supraclavicular First Rib Resection; Evaluation and Management of Venous Thoracic Outlet Syndrome; How Common is Thoracic Outlet Syndrome?; Surgical Technique: Minimally Invasive First Rib Resection; Radiographic Evaluation of Thoracic Outlet Syndrome; Evaluation and Management of Arterial Thoracic Outlet Syndrome; and more!