Name: An Ex Vivo 3D Tumor Microenvironment-Mimicry Culture to Study TAM Modulation (en Inglés)
Price: 177557.00 COP
Availability: InStock
Author: Yang, Lili ; Li, Yan-Ruide
ISBN: 9789994982899

portada An Ex Vivo 3D Tumor Microenvironment-Mimicry Culture to Study TAM Modulation (en Inglés)

An Ex Vivo 3D Tumor Microenvironment-Mimicry Culture to Study TAM Modulation (en Inglés)

Formato

Libro Físico

Autor

Lili Yang

Yan-Ruide Li

Editorial

Eliva Press

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.5 cm

Peso

0.14 kg.

ISBN13

9789994982899

Categorías

Medicina: cuestiones generales

An Ex Vivo 3D Tumor Microenvironment-Mimicry Culture to Study TAM Modulation (en Inglés)

Lili Yang (Autor) · Yan-Ruide Li (Autor) · Eliva Press · Tapa Blanda

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Reseña del libro "An Ex Vivo 3D Tumor Microenvironment-Mimicry Culture to Study TAM Modulation (en Inglés)"

Tumor-associated macrophages (TAMs) accumulate in the solid tumor microenvironment (TME) and have been shown to promote tumor growth and dampen antitumor immune responses. TAM-mediated suppression of T-cell antitumor reactivity is considered to be a major obstacle for many immunotherapies, including immune checkpoint blockade and adoptive T/CAR-T-cell therapies. An ex vivo culture system closely mimicking the TME can greatly facilitate the study of cancer immunotherapies. Here, we report the development of a 3D TME-mimicry culture that is comprised of the three major components of a human TME, including human tumor cells, TAMs, and tumor antigen-specific T cells. This TME-mimicry culture can readout the TAM-mediated suppression of T-cell antitumor reactivity, and therefore can be used to study TAM modulation of T-cell-based cancer immunotherapy. As a proof-of-principle, the studies of a PD-1/PD-L1 blockade therapy and a MAO-A blockade therapy were performed and validated.