Name: Gold(i, III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (en Inglés)
Price: 457870.00 COP
Availability: InStock
Author: Ferraz de Paiva, Raphael Enoque
ISBN: 9783030008529

portada Gold(i, III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (en Inglés)

Formato

Libro Físico

Autor

Raphael Enoque Ferraz de Paiva

Editorial

Springer

Idioma

Inglés

N° páginas

151

Encuadernación

Tapa Dura

Dimensiones

23.4 x 15.6 x 1.3 cm

Peso

0.45 kg.

ISBN13

9783030008529

Categorías

Análisis espectral | espectroquímica
Química orgánica
Bioquímica

Gold(i, III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (en Inglés)

Raphael Enoque Ferraz de Paiva (Autor) · Springer · Tapa Dura

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Reseña del libro "Gold(i, III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins (en Inglés)"

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N N and C N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C-S coupling.