Name: Astrocytes in cns Disorders (en Inglés)
SKU: 63800878
Price: 385189.00 COP
Availability: InStock
Author: Brenner Michael,Parpura Vladimir

portada Astrocytes in cns Disorders (en Inglés)

Formato

Libro Físico

Editorial

Mdpi Ag

Autor

Brenner Michael,Parpura Vladimir

Idioma

Inglés

N° páginas

468

Encuadernación

Tapa Dura

ISBN13

9783725822973

Astrocytes in cns Disorders (en Inglés)

Brenner Michael,Parpura Vladimir (Autor) · Mdpi Ag · Tapa Dura

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Reseña del libro "Astrocytes in cns Disorders (en Inglés)"

Over the past 30 years, astrocytes have emerged from a supporting role to co-starring with neurons and oligodendrocytes as players in CNS disorders. Dysfunction of astrocytes is now implicated in disorders once thought to be solely of neuronal origin, such as epilepsy, amyotrophic lateral sclerosis, and depression. It is also implicated in disorders previously ascribed solely to oligodendrocytes, like multiple sclerosis, vanishing white matter disease, and megalencephalic leukoencephalopathy with subcortical cysts. In some instances, the disease cause is a defect originating in astrocytes. The first and perhaps most definitive example is Alexander disease, in which coding mutations in the GFAP gene can cause massive dysmyelination and perturb multiple neuronal circuits. In other instances, induced disruption of normal astrocyte functions, such as glutamate or potassium transport, exacerbates the disease process. The purpose of this Special Issue is to illustrate the broad-ranging involvement of astrocytes in CNS disorders. Understanding their role in a variety of CNS disorders will be informative both for revealing normal interactions between astrocytes and other CNS cell types, and for identifying therapeutic targets.