Name: Decoding the Antibody Repertoire: High Throughput Sequencing of Multiple Transcripts from Single B Cells (en Inglés)
Price: 457870.00 COP
Availability: InStock
Author: Dekosky, Brandon
ISBN: 9783319864211

portada Decoding the Antibody Repertoire: High Throughput Sequencing of Multiple Transcripts from Single B Cells (en Inglés)

Formato

Libro Físico

Autor

Brandon Dekosky

Editorial

Springer

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

23.4 x 15.6 x 0.6 cm

Peso

0.17 kg.

ISBN13

9783319864211

Categorías

Génetica médica
Inmunología
Genética (no médica)

Decoding the Antibody Repertoire: High Throughput Sequencing of Multiple Transcripts from Single B Cells (en Inglés)

Brandon Dekosky (Autor) · Springer · Tapa Blanda

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Reseña del libro "Decoding the Antibody Repertoire: High Throughput Sequencing of Multiple Transcripts from Single B Cells (en Inglés)"

This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases.Previous methods for high-throughput immune repertoire sequencing have been unable to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. The author directly addresses these limitations by designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells. The techniques developed in this work have enabled comprehensive interrogation of human B-cell repertoires and have been applied for rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.