Name: Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement de Harinath More Anilkumar Shinde(Ks Omniscriptum Publishing) (en Inglés)
Price: 199307.00 COP
Availability: InStock
Author: Shinde Anilkumar,Jarag Ravindra,More Harinath
ISBN: 9786207640492

portada Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement de Harinath More Anilkumar Shinde(Ks Omniscriptum Publishing) (en Inglés)

Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement de Harinath More Anilkumar Shinde(Ks Omniscriptum Publishing) (en Inglés)

Formato

Libro Físico

Editorial

Ks Omniscriptum Publishing

Autor

Shinde Anilkumar,Jarag Ravindra,More Harinath

Idioma

Inglés

Encuadernación

Tapa Blanda

ISBN13

9786207640492

Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement de Harinath More Anilkumar Shinde(Ks Omniscriptum Publishing) (en Inglés)

Shinde Anilkumar,Jarag Ravindra,More Harinath (Autor) · Ks Omniscriptum Publishing · Tapa Blanda

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Reseña del libro "Formulation of Nitrendipin Nanocrystals for Solubility and Dissolution Enhancement de Harinath More Anilkumar Shinde(Ks Omniscriptum Publishing) (en Inglés)"

The objective of present work was to prepare nanocrystals of Nitrendipin (NTD) to enhance its solubility and dissolution rate with aim of dose reduction and minimising the side effects associated with it's oral administration. The optimised nanocrystals formulation had particle size 335nm, PDI 0.262, practical yield 85%, and ZP in the range of of -20 to -45mv. X-Ray diffraction studies (XRPD) and Differential scanning calorimetry (DSC) studies suggested nanocrystal formation and absence of crystalline peaks, indicating loss of crystallinity, additionally confirmed by scanning electron microscopy (SEM). Nanocrystals showed 30.45 fold enhancements in aqueous solubility, and 38.5 fold in phosphate buffer pH 1.2, as compared to pure NTD. In vitro release studies have demonstrated 96.186% cumulative drug release within 60 min from nanocrystals compared to 22.17% from pure NTD. Stable NTD nanocrystals formulated by anti-solvent precipitation method shows improved solubility and dissolution. It has been concluded that NTD nanocrystals were obtained with significant improvement in saturation solubility and drug losing it's crystalline nature, when compared with plain drug.