Name: In Search of Selective 11β-Hsd 1 Inhibitors Without Nephrotoxicity: An Approach to Resolve the Metabolic Syndrome by Virtual Based Screening (en Inglés)
SKU: 62655721
Price: 172448.00 COP
Availability: InStock
Author: Rakesh Jagtap; Harun Patel; Kiran Dhangar

portada In Search of Selective 11β-Hsd 1 Inhibitors Without Nephrotoxicity: An Approach to Resolve the Metabolic Syndrome by Virtual Based Screening (en Inglés)

In Search of Selective 11β-Hsd 1 Inhibitors Without Nephrotoxicity: An Approach to Resolve the Metabolic Syndrome by Virtual Based Screening (en Inglés)

Formato

Libro Físico

Editorial

Lap Lambert Academic Publishing

Autor

Rakesh Jagtap; Harun Patel; Kiran Dhangar

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

ISBN13

9783659790010

In Search of Selective 11β-Hsd 1 Inhibitors Without Nephrotoxicity: An Approach to Resolve the Metabolic Syndrome by Virtual Based Screening (en Inglés)

Rakesh Jagtap; Harun Patel; Kiran Dhangar (Autor) · Lap Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "In Search of Selective 11β-Hsd 1 Inhibitors Without Nephrotoxicity: An Approach to Resolve the Metabolic Syndrome by Virtual Based Screening (en Inglés)"

Over expression of 11β-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11β-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11β-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11β-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski's rule and ADME prediction implemented to find out the potent and selective 11 β-HSD 1 analog of corosolic acid without nephrotoxicity.