Name: Molecular Targets in Protein Misfolding and Neurodegenerative Disease (en Inglés)
Price: 338217.00 COP
Availability: InStock
Author: Pierfausto Seneci
ISBN: 9780128001868

portada Molecular Targets in Protein Misfolding and Neurodegenerative Disease (en Inglés)

Molecular Targets in Protein Misfolding and Neurodegenerative Disease (en Inglés)

Formato

Libro Físico

Editorial

Academic Press

Autor

Pierfausto Seneci

Año

2014

Idioma

Inglés

N° páginas

314

Encuadernación

Tapa Dura

ISBN13

9780128001868

N° edición

Categorías

Medicina preclínica: ciencias básicas

Molecular Targets in Protein Misfolding and Neurodegenerative Disease (en Inglés)

Pierfausto Seneci (Autor) · Academic Press · Tapa Dura

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Reseña del libro "Molecular Targets in Protein Misfolding and Neurodegenerative Disease (en Inglés)"

Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseasesProvides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potentialProvides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical developmentProvides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease areaContains a more thorough description of the therapeutic relevance of ~10 specific molecular targets