Name: Patients with Autosomal Dominant Polycystic Kidney Disease (en Inglés)
Price: 141869.00 COP
Availability: InStock
Author: Pandita, Shewata
ISBN: 9787238457455

portada Patients with Autosomal Dominant Polycystic Kidney Disease (en Inglés)

Formato

Libro Físico

Autor

Shewata Pandita

Editorial

Akhand Publishing House

Idioma

Inglés

N° páginas

234

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 1.2 cm

Peso

0.32 kg.

ISBN13

9787238457455

Categorías

Medicina renal y nefrología

Patients with Autosomal Dominant Polycystic Kidney Disease (en Inglés)

Shewata Pandita (Autor) · Akhand Publishing House · Tapa Blanda

Libro Nuevo

$ 141.869

$ 236.448

Ahorras: $ 94.579

40% descuento

Envío normal

Origen: Estados Unidos (Costos de importación incluídos en el precio)

Se enviará desde nuestra bodega entre el Lunes 01 de Julio y el Lunes 15 de Julio.

Lo recibirás en cualquier lugar de Colombia entre 1 y 5 días hábiles luego del envío.

Reseña del libro "Patients with Autosomal Dominant Polycystic Kidney Disease (en Inglés)"

Autosomal Dominant Polycystic Kidney Disease (ADPKD) accounts for 2.6% of thepatients with Chronic Kidney Disease in India. The disease is caused by pathogenicsequence variants in either PKD1 or PKD2 gene. The primary aim of the presentstudy was to evaluate PKD1 and PKD2 genes to identify the disease causing variantsin patients of ADPKD. A significant phenotypic variability is observed in patients ofADPKD with respect to progression of the disease. Genetic modifying factors arereported to be associated with this variability and thus, identification of these factorscould inform about targets for intervention. Given this, an attempt was made toinvestigate the role of Glu298Asp (c.894G>T) polymorphism of NOS3 gene and twopromoter polymorphisms (-2578C>A and -1154G>A) of VEGF gene in progressionof disease in ADPKD patients.PKD1 and PKD2 variants were analyzed by direct gene sequencing and/or multiplexligation-dependent probe amplification (MLPA) in 125 unrelated patients of ADPKD.The pathogenic potential of the variants was evaluated computationally using multiplein silico web based prediction tools and by segregation analysis. NOS3 and VEGFgene polymorphisms were genotyped in 123 patients of ADPKD and 100 healthycontrols. Genotyping was carried out using the amplification refractory mutationspecificpolymerase chain reaction (ARMS-PCR) for NOS3 and restriction fragmentlength polymorphism (RFLP) for VEGF gene polymorphisms. Comparison of allele, genotype and haplotype frequencies between groups was done by using Chi-Square(χ2) test or Fisher's exact test.