Name: Proapoptotic and antiangiogenic plant proteins for cancer therapy (en Inglés)
SKU: 57299415
Price: 245097.00 COP
Availability: InStock
Author: Ishwar Kalyani, Manjula
ISBN: 9786139843275

portada Proapoptotic and antiangiogenic plant proteins for cancer therapy (en Inglés)

Proapoptotic and antiangiogenic plant proteins for cancer therapy (en Inglés)

Formato

Libro Físico

Autor

Manjula Ishwar Kalyani

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

144

Encuadernación

Tapa Blanda

Dimensiones

22.9x15.2x0.9 cm

Peso

0.22 kg.

ISBN13

9786139843275

Categorías

Bioquímica

Proapoptotic and antiangiogenic plant proteins for cancer therapy (en Inglés)

Manjula Ishwar Kalyani (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Proapoptotic and antiangiogenic plant proteins for cancer therapy (en Inglés)"

The Ehrlich Ascites Tumor model is an excellent model system both in vivo & in vitro for rapid screening & testing of anti-tumor & antiangiogenic drugs especially with respect to ascites tumors. The present investigation, we are reporting the identification of a 15kDa protein in the water extract of Bacopa monnieri. We have defined the antiproliferative and apoptotic mechanism of BmP in EAT cells. BmP induces oligonucleosomal fragmentation of DNA in EAT cells due to caspase-3 activated endonucleases. The BmP also showed antiangiogenic activity and antiproliferative action by repressing VEGF secretion in ascites fluid of EAT bearing mice. It also exerted its antiangiogenic activity via NF-kB pathway. These findings could demonstrate a pharmacological mechanism involved in proapoptotic induction and angioinhibitory effects of the protein component isolated from Bacopa monnieri. Further invention needs to be focused on the identification, characterization of the BmP coding mRNA for its possible subcloning and expression in a suitable host for therapeutic application.