Name: Quantification of Amlodipine and Indapamide in Human Plasma by HPLC (en Inglés)
SKU: 66200576
Price: 216809.00 COP
Availability: InStock
Author: Pethani, Trupesh; Thumar, Mayuri; Varsani, Ravi
ISBN: 9786202438360

portada Quantification of Amlodipine and Indapamide in Human Plasma by HPLC (en Inglés)

Quantification of Amlodipine and Indapamide in Human Plasma by HPLC (en Inglés)

Formato

Libro Físico

Editorial

LAP Lambert Academic Publishing

Autor

Pethani, Trupesh; Thumar, Mayuri; Varsani, Ravi

Idioma

Inglés

N° páginas

104

Encuadernación

Tapa Blanda

Dimensiones

22.9x15.2x0.6 cm

ISBN13

9786202438360

Quantification of Amlodipine and Indapamide in Human Plasma by HPLC (en Inglés)

Pethani, Trupesh; Thumar, Mayuri; Varsani, Ravi (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Quantification of Amlodipine and Indapamide in Human Plasma by HPLC (en Inglés)"

A simple, sensitive, and selective HPLC method was developed and validated for the simultaneous estimation of Amlodipine besylate (AML) and Indapamide (IND) in human plasma for application in pharmacokinetic, bioequivalence, and bioavailability studies. AML, a calcium channel blocker, and IND, a thiazide-like diuretic, are widely prescribed in combination for hypertension management. The method employed liquid-liquid extraction using diethyl ether and dichloromethane, followed by chromatographic separation on a C18 column with a methanol-octane sulfonic acid mobile phase (79:21 v/v) at a flow rate of 1.2 mL/min and UV detection at 240 nm. The retention times for AML, IND, and the internal standard (carbamazepine) were 8.9, 2.9, and 3.6 min respectively. The method was linear over 0.075-15 ng/mL for AML and 0.3-60 ng/mL for IND, with correlation coefficients >=0.998. Validation as per USFDA guidelines demonstrated accuracy, precision, recovery, stability, and selectivity within acceptance criteria. This validated HPLC method is robust and suitable for routine analysis of AML and IND in plasma, supporting clinical and regulatory studies.